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A very small study (10 individuals) found that 7 days of 1-hour ice baths was associated with lower programmed cell death (apoptosis) and greater cleanup of cellular waste (autophagy).
Summary: https://www.uottawa.ca/about-us/news-all/cold-plunges-actually-change-your-cells-uottawa-study-finds
Original paper: https://advanced.onlinelibrary.wiley.com/doi/10.1002/adbi.202400111
About usCold plunges actually change your cells, uOttawa study finds | About usA new study conducted at the Human and Environmental Physiology Research lab (HEPRU) at the University of Ottawa has unveiled significant findings on the effects of cold water acclimation on autophagic (the cells’ recycling system, which promotes cellular health) and apoptotic (the programmed cell death that gets rid of damaged cells) responses in young males. The research highlights the potential for cold exposure to enhance cellular resilience against stress.The study, conducted by Kelli King, postdoctoral fellow, and Glen Kenny, Full Professor at uOttawa’s School of Human Kinetics and Director of HEPRU, involved ten healthy young males who underwent cold-water immersion at 14°C (57.2°F) for one hour across seven consecutive days. Blood samples were collected to analyze the participants' cellular responses before and after the acclimation period.“Our findings indicate that repeated cold exposure significantly improves autophagic function, a critical cellular protective mechanism,” says Professor Kenny. “This enhancement allows cells to better manage stress and could have important implications for health and longevity.”